By Dr. Mukesh  Mallik, Master in Applied Neuroscience student

Abstract

Physiological aging has become a general term in recent years that encompasses all the modifications that occur in an old-age organism. It is now clear that new health issues affecting the aging population are starting to emerge in developing and industrialised countries. Dementia is potentially one of the big issues. Different types of dementia contribute to learning deficiency, memory loss, low attention span, speech impairment, and impaired problem-solving abilities sooner or later. Normal ageing is a physiological phenomenon that often includes many neurological conditions in demented patients with the same kind of signs and consequences that many researchers are seeking to mitigate. We are trying to highlight some of the newest aspects of therapeutic techniques in this analysis that can stimulate neuroregeneration.

Neuroregeneration is a fairly new idea including neurogenesis, neuroplasticity and neurorestoration (implantation of viable cells as a therapeutic approach). In the brain of patients suffering from Alzheimer’s or Parkinson’s disease, neurogenesis and neuroplasticity are impaired and correlate with low endogenous defence, as a consequence of decreased expression of the growth factor. We hypothesize however that the brain has a “neuroregenerative reserve” that could be targeted by growth factor or neurorestoration therapies for stem cells, at least in the early and medium stage of disease.

In this study, through a systematic analysis of various scientific literature, we review the latest data on all three aspects of neuroregeneration in Alzheimer’s disease.

Download the full research study here: Dr. Mukesh Mallik (2021). Neuroregeneration New Therapeutics for Alzheimer’s Dementia. SAERA

 

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